Application of capacitive micromachined ultrasound transducers for biosensors

Monday, October 30, 2017 - 13:00
Rectorate Hall (K. Donelaicio St. 73-402 room)

Author, Institution: Evaldas Sapeliauskas, Kaunas University of Technology

Science Area, Field of Science: Technological Sciences, Electrical and Electronics Engineering – 01T

Summary of the Doctoral Thesis: Summary

Scientific supervisor: Prof. Dr. Darius Viržonis (Kaunas University of Technology, Technological Sciences, Electronic Engineering – 01 T)

Dissertation Defence Board of Electrical and Electronic Engineering Science Field:
Assoc. Prof. Dr. Elena Jasiūnienė (Kaunas University of Technology, Technological sciences, Electrical and Electronic Engineering, 01T) – chairwoman;
Prof. Dr. Liudas Mažeika (Kaunas University of Technology, Technological sciences, Electrical and Electronic Engineering, 01T);
Prof. Dr. Vaidotas Marozas (Kaunas University of Technology, Technological sciences, Electrical and Electronic Engineering, 01T);
Assoc. Prof. Dr. Asta Kaušaitė-Minkštimienė (Vilnius University, Physical Sciences, Chemistry – 03P);
Prof. Dr. Rimantas Kodžius (Shanghai University, Biomedical Science, Biology – 01B).

The doctoral dissertation is available on the internet and at the library of Kaunas University of Technology (K. Donelaičio g. 20,Kaunas)

Many chemical, biological and biochemical sensors are based on specific materials interactions. For the detection of interactions, may be used mass measurement resonant chemical sensors (i.e., gravimetric sensors) with functionalized surface that specifically adsorb target molecules from the environment. In essence, these are electromechanical resonant systems, potentially infinite variety of functional materials, adapted in various fields. Appropriate functional materials, immobilized on the surface of the sensor, must be adapted to measure the various analytes (chemical, biochemical components, which should be determined during the analytical procedure). The specific interaction of target material molecules with the microelectromechanical structure helps to detect the most commonly found biological elements, such as enzymes, antibodies, DNA oligonucleotides, proteins. The key engineering and fundamental knowledge was acquired in the doctoral dissertation research that are required for the fabrication and usage of CMUT structures for bio sensing applications. Functionalization methods of the biosensor were developed, the measured signal informativity was justified and its usefulness for analyte detection were determined. The technological concept was justified by demonstration of operating prototype “comb-type” sensor with integrated microchannel in a liquid media in the real time while at the same time measuring the biochemical interactions using other devices.